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Abstract : We aimed to determinecharacterization of culture-positive multidrug-resistant tuberculosis (MDR-TB) patients from a drug-resistant tuberculosis (DR-TB) centre of India. We enrolled 436 TB patients and selected 395 subjects after inclusion and exclusion criteria. Descriptive statistics were employed to investigate the social-demographics and clinical feature of culture-positive TB patients and its risk factors.Mean age of patients was 43.6±12.7 years and 61.5% were males.A total of 108 (27.3%) patients were smokers while 26 (6.6%) were ex-smokers and remaining were non-smokers (66.1%).Most common symptoms were cough with expectoration 365 (92.4%). Complaints like fever (78%), haemoptysis (30%), and weight loss (63%) were present. 21% (n=82) population has family history of TB. Co-morbidities were present in 94 (23.8%) patients and diabetes (n=37) was the most common comorbidity. Out of 395, 125 cases of drug sensitive pulmonary tuberculosis and 270 cases were MDR-TB. In smear grading 204 cases were presented 2+ or 3+ positive, 191 were 1+ or scanty. Out of the 395 sample, 364 samples were found to be culture positive which were further analyzed by drug susceptibility testing (DST) of which 251, 243 and 247 were found to be resistant towards rifampicin (RIF), isoniazid (INH), and ethambutol (EMB), respectively.Our data suggests that there is a sufficient number of MDR-TB patients in the studied. The majority of MDR-TB resulted from people failing to take their anti-TB medications properly. Hence, decreasing alcohol intake, receiving more education, TB advocacy & communication, more testing and notification, and TB control programmes are indispensable to defeatthe TB.