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Abstract : Padang Pariaman is one of the regencies/cities that has quite high cases of tuberculosis (TBC). The spread of tuberculosis will be difficult to identify if the data is presented only in numbers or tables. This study aims to determine the mapping of the distribution of tuberculosis in the Padang Pariaman Regency. This research is qualitative research using the concept of a Geographical Information System that can visualize, explore, sort data, and analyze spatially. The results show that the distribution of tuberculosis in general has an adjacent pattern, which is mostly the western part of Padang Pariaman Regency. Lubuk Alung Sub-sub-district (102 cases) and Batang Anai (91 cases) were the sub-sub-district that had the most cases and Padang Sago Sub-district (17 cases) and Batang Gasan Sub-district (21 cases) had the lowest. The level of distribution in Padang Pariaman Regency is influenced by community interaction, proximity, and population density. The results of the spatial analysis that resulted in the mapping made the distribution of tuberculosis easier to control, resources could be used more effectively, and made it easier for health workers to intervene in health programs.