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Abstract : IL-13 is a Th-2 cytokine commonly associated with allergic disorders. TLR-2 is a member of the toll-like receptor protein family, providing 1st line of defense against pathogens. IL-13 and TLR-2 are known to play roles in tumorigenesis and progression. The present study was designed to investigate clinicopathological features of lymphomas and the association of IL-13 2044 G/A and TLR-2 Arg677Trp polymorphism with lymphoma susceptibility. In total, eighty-five lymphoma patients from Nuclear Medicine Oncology and Radiotherapy Institute(NORI), Islamabad, and 90 controls were included in the study. Restriction fragment length polymorphism (RFLP) for the IL-13 gene after PCR analysis, whereas Tetra-ARMS PCR (Tetra-primer amplification refractory mutation system PCR) for TLR-2 gene was performed on purified DNA extracted from blood samples. Out of 85 lymphoma patients, 70.58% of cases were of non-Hodgkin lymphoma (NHL) and 29.42% of Hodgkin lymphoma (HL) type. Among NHL, diffuse large B cell lymphoma (DLBCL) was the prevalent subtype (80%), while Mix cellularity (MC) was the most prevailing HL type (88%). The majority of the patients were of low socioeconomic status. Nodal involvement was common (74.12%) for both types, with the commonly affected nodal site being cervical. Genotype analysis of IL-13 2044 G/A polymorphism demonstrated no association with lymphoma [χ2=2.86, P-value=0.23] as well as in the DLBCL group [χ2=3.141, P-value=0.201]. However, the analysis of allelic frequencies in DLBCL patients regarding IL-13 2044G/A polymorphism showed a significant association of the A allele [χ2=4.6, p-value=0.03]. Similarly, no association of TLR-2 Arg677Trp polymorphism was found in lymphoma patients [χ2=0.51, P-value=0.43] and in DLBCL patients [χ2=0.02, P-value=0.87]. Although no association of these polymorphisms with lymphoma was seen, IL-13 2044G/A polymorphism had a one-fold risk for lymphoma [χ2=0.837, P-value=0.042, OR=1.045(95%Cl)].