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Abstract : Background: Thyroid disorders are one of the most prevalent endocrinopathies across the world. Overt hypothyroidism has been associated with cardiovascular disease, but the association of subclinical hypothyroidism with cardiovascular disease is unclear and controversial. Therefore, the present study was aimed to determine the level of HsCRP and insulin resistance in subclinical hypothyroid subjects and compare it with healthy controls. Materials and Methods: An observational cross-sectional study was conducted involving 70 Subclinical hypothyroid patients (SCH) and 100 healthy controls. Newly diagnosed cases of subclinical hypothyroidism not taking any treatment, in the age group of 20 – 60 years were included in the study. 100 healthy cases of same age group were taken as control Fasting blood sample from both the groups of patient was collected for estimation of T3, T4, TSH, total cholesterol (TC), triglycerides, high density lipoprotein (HDL), high sensitive C reactive protein (HsCRP), lipoprotein A , fasting blood glucose and insulin. Results: The mean value of serum TSH are significantly higher in subclinical hypothyroid (SCH) patients (TSH 7.90 ± 1.25 µIU/ml) compared to that of control participants (TSH 2.70 ± 0.77 µIU/ml ).The serum level of T3 and T4 of the two groups were within the normal reference range. The mean serum HsCRP level of patients with SCH was higher than those of control (4.19 ± 0.68 mg/L and 1.71 ± 0.41 mg/L respectively p0.0001) The mean insulin level of subject with SCH were also higher than that of control subjects (7.91 ± 1.79 µu/l and 5.55 ± 1.70 µu/l respectively, p0.0001). HOMA-IR in the SCH group was significantly higher than the control group (1.78 ± 0.47 and 1.24 ± 0.39 respectively, p0.0001). Pearson correlation test was performed among TSH, insulin, HOMA-IR, HsCRP in the subclinical group. We found positively correlation of TSH with serum insulin, HOMA-IR and HsCRP .The correlation of TSH with insulin level and HOMA-IR was statistically significant whereas with HsCRP the p value was 0.06. Conclusions: we concluded that low-grade inflammation starts in the early stages of hypothyroidism, resulting in elevated HsCRP level which may result in the future development of atherosclerosis leading to cardiovascular morbidity.