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Abstract : Psoriasis is a long-lasting ailment of the skin that causes rashes with itching, and scaly patches, usually on the scalp, trunk, elbows, and knees. Aquasomes are triple-layered self-amassed nanoparticulate drug delivery systems, that can deliver medications without negotiating with their conformational veracity. Aquasomes were fabricated using DCP as the core, and trehalose as the coating material. Dithranol is a widely used drug to regulate the growth of psoriasis. In the current study, an aquasomal gel was developed by Carbopol as the gelling agent. Compatibility of the medication with formulation components was judged by employing FTIR, and DSC. Size and zeta potential of aquasomes were in range to predict the fabrication of efficient preparation. In vitro drug release from AQT1D1 released 88% of dithranol in a sustained manner indicating preparation of a controlled release formulation. Gel characterization studies exhibited AQTG1 had a drug content of 98.41±1.74%, spreadability of 24597.196±5.46 (gm.cm/sec), and a viscosity of 0.3342±0.011 cPoise signifying manufacture of satisfactory gel formulations. Acute dermal toxicity studies showed no sign of irritation, erythema, redness, or mortality while antipsoriatic studies on animal models displayed excellent control of the imiquimod-induced psoriatic condition by the AQTG1 gel formulation.