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Abstract : Citrus medica commonly known as citron is widely distributed in the himalayan regions of India. It contains various phytoconstituents like limonene, hesperetin, Vitamin C, phenolics, flavonones, iso-limonene, pectin, linalool, decanal, and nonanal etc. It is frequently used in traditional systems of medicine for the treatment of cardiac, thyroid, and oestrogen disorders. These activities is due to presence of phenolic and flavanoids content in it. It is also mutagenic and exhibits good antioxidant properties. The plant leaves, peels, fruits and their seeds have several pharmacological effects such as antioxidant (reduces reactive oxygen species and malondialdehyde), analgesic and anti-inflammatory activities (inhibitis DPPH and hydrogen peroxide radical scavenging), antilipidaemic (by inhibiting HMG-CoA reductase) and estrogenic activity (increase vaginal epithelial cell cornification and uterine weight) etc. The purpose of this review is to highlight the source, geographical indication, phytochemistry, traditional uses, pharmacological effects and numerous nutraceuticals application of Citrus medica and its main constituent Vitamin C.