Background: Holarrhena antidysenterica is an herbal plant which found to be effective against several diseased conditions like anti-diabetic, anti-diarrhea, analgesic activity, anti-microbial, antihypertensive activity, anti-inflammatory, and anti-malarial, the whole plant of Holarrhena antidysenterica contains medicinal value like seeds, callus, stem, leaf and bark. It originates from the family Apocynaceae. It is used from ancient time and their traditional name was kada, kurchi or kutaj. Objectives: The goal of this study is to precise all pharmacological activities with therapeutic uses. Material and Methods: A bibliographic investigation from recognized scientific databases PubMed, ScienceDirect, Google scholar, etc. Clinical databases were also included in previous research papers from 1980 -2022. Result: In this review, paper explores the knowledge about novtheel use of Holarrhena antidysenterica which relates to their new pharmacological action and, harmacognostic studies (about stem, bark, leave, flower & root) including their toxicity studies. Conclusion: Holarrhena Antidysenterica is one the important plant for the treatment of various diseases like malaria, constipation, pile, diabetes, dysentery and other disease. This medicinal plant found very effect against worms from ancient time.