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Abstract : Physiological, physicochemical, and biopharmaceutical aspects can be used to classify the variables that determine how well oral medications are absorbed and metabolised. The physical, chemical, and biological factors influencing permeability and solubility the purpose of this study was to elucidate the rate-limiting mechanism in oral biopharmaceutical classification system absorption. Due to its particular anatomical and physiological activities, designing the ocular surface and evaluating its performance for ophthalmic ointment medicinal solutions prepared with a range of bases provide specific challenges. Drug assay, content homogeneity, API, rheological characteristics, in vitro drug release, and in vitro drug permeation were among the quality and performance parameters examined. the physicochemical and release parameters, the in vitro drug release constant, and quality and performance qualities. drug dissolution vessel to conduct experiments using a USP paddle apparatus, drug release characteristics for products with various formulations and manufacturing processes to gauge the effects of this altered vessel environment while still keeping the vessel dimensions within the required specifications. In vitro dissolution/release testing of innovative administrations will be thoroughly reviewed in this article, including both compendial and non-compendial approaches. This work proposes a novel type of in vitro-in vivo correlation (IVIVC): the relationship between the in vitro parent drug dissolution data and the in vivo pharmacokinetic data of the medication's metabolite. Stability tests that ensure the maintenance of the product's quality, safety, and efficacy over the shelf life are necessary for any pharmaceutical product to be accepted and licenced.